Research Overview

Neurodegenerative diseases such as Alzheimer's disease can significantly alter a person's quality of life as they age. Our research focuses on understanding how these diseases affect individuals and gain insight on how to provide effective treatment and help them cope. Using mice models, we investigate how mice develop strategies to complete difficult tasks once they develop neurodegenerative diseases. We are also looking at neuromodulatory systems (e.g. dopamine, norepinephrine, serotonin) affect and effect behavioral changes as the brain tries to adapt to stress exposure or addiction.

Staff Highlight

Dr. Adam Z. Weitemier Associate Professor

Email:

aweitem[at]tmu.ac.jp

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(Researchgate Profile) (ResearchMap Profile) (TMU Faculty Profile) (Research Blog)

Lab Information: Department Laboratory Page (English) (Japanese)

Recent Publications

1. Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy 

Grigorii Sultanakhmetov, Sophia Jobien M Limlingan, Aoi Fukuchi, Keisuke Tsuda, Hirokazu Suzuki, Iori Kato, Taro Saito, 

Adam Z Weitemier, Kanae Ando. Brain Communications, 6(3), Apr 17, 2024

2. Smartphone-enabled Web-based simulation of cellular neurophysiology for laboratory course and its effectiveness

Takayuki Yamamoto, Adam Weitemier, Makoto Kurukawa. Journal of Undergraduate Neuroscience Education. 

21(2): A151-A158, May 2023

3.  Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier's disease, causes behavioral abnormalities and a hyper-dopaminergic state 

Kazuo Nakajima, Mizuho Ishiwata, Adam Z. Weitemier, Hirotaka Shoji, Hiromu Monai, Hiroyuki Miyamoto, Kazuhiro Yamakawa, Tsuyoshi Miyakawa, Thomas J. McHugh, Tadafumi Kato. Human Molecular Genetics, 30(18) 1762-1772, Sep 2021  

4. A hypothalamic novelty signal modulates hippocampal memory 

Shuo Chen, Linmeng He, Arthur J. Y. Huang, Roman Boehringer, Vincent Robert, Marie E. Wintzer, Denis Polygalov, Adam Z. Weitemier, 

Yanqiu Tao, Mingxiao Gu. Nature, 586(7828) 270, Oct 2020  

5. Visualization of Intra-neuronal Motor Protein Transport through Upconversion Microscopy 

Xiao Zeng, Shuo Chen, Adam Weitemier, Sanyang Han, Agata Blasiak, Ankshita Prasad, Kezhi Zheng, Zhigao Yi, Baiwen Luo, 

In-Hong Yang,  Angewantde Chemie - International Edition, 58(27) 9262-9268, Jul2019  

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